Nanotechnology Applied to the Treatment of Bladder Cancer: Zinc Oxide and Innovation in Public Health
DOI:
https://doi.org/10.36489/saudecoletiva.2025v16i103p18692-18701Keywords:
Nanostructure, Urinary Bladder Neoplasms, Public HealthAbstract
Objective: To evaluate the selective antitumor activity of a zinc oxide nanostructure against bladder cancer. Method: The nanomaterial was synthesized by coprecipitation and morphologically characterized by scanning and transmission electron microscopy. Cytotoxicity was evaluated in human bladder carcinoma cell lines (T24) and normal renal fibroblasts (Vero). The mechanism of cell death was investigated through nuclear morphometric analysis. Results: The nanomaterial exhibited a laminar morphology. The MTT assay demonstrated significant selective cytotoxicity against T24 cells, with approximately 65% reduction in cell viability at 200 µg mL⁻¹, while maintaining low toxicity in Vero cells. Nuclear morphometric analysis indicated that the nanomaterial predominantly induces cell death by apoptosis. Conclusion: The laminar zinc oxide nanostructure demonstrated promising therapeutic potential, combining high selective antitumor activity and low toxicity, which supports its use in the development of more accessible treatments for bladder cancer.
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