Resposta Vacinal ao Vírus da Hepatite B em População do Arquipélago do Marajó, Amazônia, Brasil

Kemere Marques Vieira Barbosa; Candida Maria Abrahão de Oliveira; Mary of Jesus de Sousa Brazil; Dickson Ciro Birth of Brito; Andreza Pine Tree Malheiros; Alex Junior Souza de Souza; Maria Luiza do Socorro Alves Lucas; Heloisa Marceliano Nunes

doi:10.36489/saudecoletiva.2025v15i95p15590-15599

Authors

Kemere Marques Vieira Barbosa Mestra em Epidemiologia e Vigilância em Saúde; Doutoranda em Virologia. Seção de Hepatologia; IEC; SVSA; MS. https://orcid.org/0000-0002-1097-2650
Candida Maria Abrahão de Oliveira Doutora em Virologia. Seção de Hepatologia; IEC; SVSA; MS. https://orcid.org/0000-0001-6253-7477
Mary of Jesus de Sousa Brazil Evandro Chagas Institute https://orcid.org/0000-0002-8002-9406
Dickson Ciro Birth of Brito Evandro Chagas Institute https://orcid.org/0000-0001-8389-3980
Andreza Pine Tree Malheiros Evandro Chagas Institute https://orcid.org/0000-0002-2643-9754
Alex Junior Souza de Souza Santo Amaro University https://orcid.org/0000-0001-6201-2777
Maria Luiza do Socorro Alves Lucas Evandro Chagas Institute https://orcid.org/0000-0002-6224-4823
Heloisa Marceliano Nunes Evandro Chagas Institute https://orcid.org/0000-0002-9335-6932

DOI:

https://doi.org/10.36489/saudecoletiva.2025v15i95p15590-15599

Keywords:

Hepatitis B, Hepatitis B vaccine, Vaccination coverage, Amazonian

Abstract

The objective of this study was to evaluate and describe the vaccination response to hepatitis B virus in a population of the municipality of Melgaço, state of Pará. This was a cross-sectional, descriptive study, with an individual survey to determine the vaccination response through the serological markers HBsAg, total anti-HBc and anti-HBs by enzyme immunoassay in 407 samples. The age range varied between 01 and 101 years, where 57.7% were female. Isolated anti-HBs with values ≥10mIU/mL was detected in 27.3%, indicating vaccination protection against HBV; 63.6% were susceptible to infection, among these, 23.2% had a vaccination card with a complete three-dose schedule, not presenting antibody titers that confirmed the effectiveness of the schedule received. The findings revealed that the vaccine response in this population was lower than expected, suggesting the need to adapt vaccination strategies to local conditions to ensure more effective coverage.

Author Biographies

Kemere Marques Vieira Barbosa, Mestra em Epidemiologia e Vigilância em Saúde; Doutoranda em Virologia. Seção de Hepatologia; IEC; SVSA; MS.

Doutoranda em virologia pelo Programa de Pós Graduação em Virologia do Instituto Evandro Chagas/SVSAJMS - PPGV/IEC (2021-2025). Mestra em Epidemiologia e Vigilância em Saúde pelo Instituto Evandro Chagas/SVSAJMS PPGEVS/IEC (2018) e graduada em Farmácia Generalista pelo Centro Universitário do Estado do Pará - CESUPA (2011). Servidor público do Instituto Evandro Chagas/IEC/SVSAJMS, desde 2013, atuando na Seção de Hepatologia]SAJ-IEP, em laboratório de sorologia e biologia molecular das hepatites virais e projetos científicos na área de Hepatites Virais.

Candida Maria Abrahão de Oliveira, Doutora em Virologia. Seção de Hepatologia; IEC; SVSA; MS.

PhD in Virology from the Evandro Chagas Institute Postgraduate Program (PPGV/IEC) (2020), Master in Biology of Infectious and Parasitic Agents from the Federal University of Pará (2009), Specialist in Public Health from the State University of Pará (1997) and Graduated in Nursing and Obstetrics from the Educational Foundation of the State of Pará (1984). Develops technical-scientific teaching and research activities at the Evandro Chagas Institute (IEC), Belém-PA, participation in the Epidemiology Service in the implementation of the Biological Specimen Receiving Center. Implementation and coordination of the Worker's Health Sector (2005 to 2014) of the Human Resources Management Service/IEC. Acting as a member of the Working Group for the implementation of the Integrated Subsystem of Health Care for Servers in Pará and full member of the Ethics Committee for Research with Human Beings of the Evandro Chagas Institute. She works as an instructor in the Laboratory Technician Course at IEC and participates as a guest in postgraduate programs at IEC/UFPA. She is currently part of the Hepatology Section Team at the Evandro Chagas Institute, S III of the Ministry of Health - Health Surveillance Secretariat; She has experience in Nursing, with an emphasis on Public Health Nursing, Epidemiology and Occupational Health.

Mary of Jesus de Sousa Brazil, Evandro Chagas Institute

Master in Epidemiology and Health Surveillance from the Evandro Chagas Institute/SVSA/MS – PPGEVS/IEC (2022). Graduated in Full Degree in Mathematics from the State University of Pará - UEPA (2006). Public servant at the Evandro Chagas Institute/IEC/SVSA/MS, since 2013, working in the Hepatology Section/SAHEP.

Dickson Ciro Birth of Brito, Evandro Chagas Institute

Graduated in Biomedicine from the Federal University of Pará - UFPA (1997). Specialization in Epidemiology at the Federal University of Pará (UFPA), from 1997 to 1998. Currently, he is a public servant at the Evandro Chagas Institute/IEC/SVS/MS, working in the Hepatology Section/SAHEP. He has experience in Clinical Analysis (Amaral Costa Laboratory - 1997 - 2013), working mainly in the areas of Biochemistry, Hematology, Urinalysis, Parasitology, Immunology and Serology. Master in Epidemiology and Health Surveillance from the Evandro Chagas Institute/SVSA/MS – PPGEVS/IEC (2022).

Andreza Pine Tree Malheiros, Evandro Chagas Institute

He holds a degree in Biology from the Federal University of Pará - UFPA (2008). He has a Master's degree in Genetics and Molecular Biology from UFPA (2013) and a PhD (in progress) in Virology. He has experience in the area of Virology and Parasitology with emphasis on the application in molecular biology of Microorganisms, working mainly on the following topics: viral hepatitis (A, B, C, D and E) and causative agents of polycystic echinococcosis.

Alex Junior Souza de Souza, Santo Amaro University

He holds a degree in Veterinary Medicine from the Federal Rural University of the Amazon (2009), a Master's degree in Animal Science from the Federal University of Pará (2011) and a PhD in Sciences from the Experimental and Comparative Pathology program at the Faculty of Veterinary Medicine and Animal Science of the University of São Paulo (2017). From 2009 to 2019, he worked as a collaborating researcher in the Hepatology Section of the Evandro Chagas Institute. He participates in the "Tropical Hepatology" group, of the directory of research groups in Brazil of the CNPq and has experience in the area of Veterinary Medicine, with an emphasis on Veterinary Pathology, Molecular Biology and One Health. He works in lines of research on viral, bacterial and parasitic hepatotropic agents, with zoonotic and/or emerging potential, of interest in human and veterinary medicine. He is a professor in the undergraduate course in Veterinary Medicine at the Universidade Santo Amaro (UNISA), a collaborating professor in the stricto sensu Postgraduate Program in One Health at UNISA, a preceptor at the Animal Pathology Laboratory of the UNISA Veterinary Hospital; and a postdoctoral fellow at the University of São Paulo (USP).

Maria Luiza do Socorro Alves Lucas, Evandro Chagas Institute

Undergraduate medical student at the Pará State University Center (CESUPA). Experience as local coordinator and finance director at the International Federation of Medical Students' Associations of Brazil (IFMSA Brazil- CESUPA). She was a monitor at the Pará Committee for Clinical, Surgical and Radiological Anatomy (CPA). Former director and liaison of the Pará Academic League of Dermatology (LAPDERM) and the Academic League of Cardiology (LAC). Monitor at the Morphofunctional Laboratory in "Introduction to the Study of Medicine", "Implications of Cell Growth and Differentiation", and "Attack and Defense" between 2023 and 2024. Volunteer researcher in the PIBIC/CNPQ 2022-2023 program, addressing the theme "Prevalence of symptoms of anxiety and depression in students at a university in the Amazon and their association with memories and learning". Currently, a research fellow in the PIBIC/IEC 2024-2025 Program, discussing the theme: "Hepatitis A: Serological survey and vaccination status in residents of a municipality in the Marajó Archipelago, Pará, Brazil".

Heloisa Marceliano Nunes, Evandro Chagas Institute

She holds a degree in Medicine from the Federal University of Pará - UFPA (1979), a master's degree in Tropical Diseases from UFPA (2005) and a PhD in Biology of Infectious and Parasitic Agents from UFPA (2016). She currently works as a physician in the Hepatology Section of the Evandro Chagas Institute, of the Secretariat for Health and Environmental Surveillance (SVSA), of the Ministry of Health. She has experience in Medicine, with an emphasis on Medicine, working mainly on the following topics: viral hepatitis A, B, C, D and E, prevalence and incidence in the Amazon, and Hydatidosis.

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