Enxaguantes Orais à Base de Cúrcuma no Tratamento da Mucosite Oral: Avanços, Mecanismos e Desafios
DOI:
https://doi.org/10.36489/saudecoletiva.2025v15i93p14881-14894Palavras-chave:
Curcuma, Curcumina, Estomatite, Antissépticos Bucais, QuimiorradioterapiaResumo
Objetivo: avaliar a eficácia dos enxaguantes orais à base de cúrcuma/curcumina na prevenção e redução da mucosite oral em pacientes submetidos à quimio-radioterapia. Métodos: realizou-se uma busca sistemática em diferentes bases de dados e literatura cinzenta, considerando estudos publicados entre 2014 e outubro de 2024. Foram selecionados ensaios clínicos e revisões da literatura que investigaram a eficácia dos enxaguantes orais contendo curcumina, excluindo estudos com outras formulações, como cápsulas e géis. Resultados e Conclusão: quatorze estudos foram incluídos. Os resultados indicam que os enxaguantes com curcumina retardam o aparecimento da mucosite e reduzem sua gravidade, embora não previnam completamente sua incidência. Esses enxaguantes são seguros, de fácil aplicação e bem tolerados. No entanto, limitações metodológicas foram observadas nesses estudos, como amostras reduzidas e variabilidade nas dosagens. Ensaios clínicos robustos são necessários para validar esses achados e otimizar a biodisponibilidade da curcumina, trazendo maior eficácia no tratamento da mucosite oral.
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